Neurobiology of Disease Anandamide-Evoked Activation of Vanilloid Receptor 1 Contributes to the Development of Bladder Hyperreflexia and Nociceptive Transmission to Spinal Dorsal Horn Neurons in Cystitis
نویسندگان
چکیده
Paulo Dinis,1,5* Ana Charrua,1,2* Antonio Avelino,1,2 Mohammed Yaqoob,3 Stuart Bevan,3 Istvan Nagy,4 and Francisco Cruz1,5 1Institute of Histology and Embryology, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal, 2Institute for Molecular and Cell Biology, University of Porto, 4150-180 Porto, Portugal, 3Novartis Institute for Medical Sciences, London WC1E 6BN, United Kingdom, 4Department of Anaesthetics and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, United Kingdom, and 5Department of Urology, Hospital São João, 4200-319 Porto, Portugal
منابع مشابه
(R)-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo.
The transient receptor potential vanilloid (TRPV) 1 receptor, a nonselective cation channel expressed on peripheral sensory neurons and in the central nervous system, plays a key role in pain. TRPV1 receptor antagonism is a promising approach for pain management. In this report, we describe the pharmacological and functional characteristics of a structurally novel TRPV1 antagonist, (R)-(5-tert-...
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